Myotonic dystrophy type 1 (DM1) is the most frequent muscular dystrophy in adults. DM1 is a multisystem disorder also affecting the heart with an increased incidence of sudden death, which has been explained with the common impairment of the conduction system often requiring pacemaker implantation; however, the occurrence of sudden death despite pacemaker implantation and the observation of major ventricular arrhythmias generated the hypothesis that ventricular arrhythmias may play a causal role as well. The aim of the study was to assess the 2-year cumulative incidence and the value of noninvasive and invasive findings as predictive factors for sudden death, resuscitated cardiac arrest, ventricular fibrillation, sustained ventricular tachycardia and severe sinus dysfunction or high-degree atrioventricular block.
METHODS/DESIGN:
More than 500 Myotonic dystrophy type 1 patients will be evaluated at baseline with a clinical interview, 12-lead ECG, 24-h ECG and echocardiogram. Conventional and nonconventional indications to electrophysiological study, pacemaker, implantable cardioverter defibrillator or loop recorder implantation have been developed. In the case of an indication to electrophysiological study, pacemaker, implantable cardioverter defibrillator or loop recorder implant at baseline or at follow-up, the patient will be referred for the procedure.
At the end of 2-year follow-up, all candidate prognostic factors will be tested for their association with the endpoints. Trial registration: ClinicalTrials.gov ID NCT00127582.
CONCLUSION: The available evidence supports the hypothesis that both bradyarrhythmias and tachyarrhythmias may cause sudden death in DM1, but the course of cardiac disease in DM1 is still unclear. We expect that this large, prospective, multicenter study will provide evidence to improve diagnostic and therapeutic strategies in Myotonic dystrophy type 1.
"Risk of arrhythmias in myotonic dystrophy: trial design of the RAMYD study"
J Cardiovasc Med (Hagerstown). 2009 Jan; 10(1): 51-8Dello Russo A, Mangiola F, Della Bella P, Nigro G, Melacini P, Bongiorni MG, Tondo C, Calò L, Messano L, Pace M, Pelargonio G, Casella M, Sanna T, Silvestri G, Modoni A, Zachara E, Moltrasio M, Morandi L, Nigro G, Politano L, Palladino A, Bellocci F
Friday
Autonomic effects of controlled fine particulate exposure in young healthy adults
Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown.
OBJECTIVE:
In this study we assessed the impact of O(3) and particulate matter exposure on HRV in humans. METHODS: In a crossover design, 50 subjects (19-48 years of age) were randomized to 2-hr controlled exposures to filtered air (FA), concentrated ambient particles (CAPs), O(3), or combined CAPs and ozone (CAPs + O(3)). The primary end point was change in HRV between the start and end of exposure. Secondary analyses included blood pressure (BP) responses, and effect modification by asthmatic status.
RESULTS:
Achieved mean CAPs and O(3) exposure concentrations were 121.6 +/- 48.0 microg/m(3) and 113.9 +/- 6.6 ppb, respectively. In a categorical analysis, exposure had no consistent effect on HRV indices. However, the dose-response relationship between CAPs mass concentration and HRV indices seemed to vary depending on the presence of O(3). This heterogeneity was statistically significant for the low-frequency component of HRV (p = 0.02) and approached significance for the high-frequency component and time-domain measures of HRV. Exposure to CAPs + O(3) increased diastolic BP by 2.0 mmHg (SE, 1.2; p = 0.02). No other statistically significant changes in BP were observed. Asthmatic status did not modify these effects.
CONCLUSION:
The potentiation by O(3) of CAPs effects on diastolic BP and possibly HRV is of small magnitude in young adults. Further studies are needed to assess potential effects in more vulnerable populations.
Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone.
Environ Health Perspect. 2009 Aug; 117(8): 1287-92Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, Mittleman MA
OBJECTIVE:
In this study we assessed the impact of O(3) and particulate matter exposure on HRV in humans. METHODS: In a crossover design, 50 subjects (19-48 years of age) were randomized to 2-hr controlled exposures to filtered air (FA), concentrated ambient particles (CAPs), O(3), or combined CAPs and ozone (CAPs + O(3)). The primary end point was change in HRV between the start and end of exposure. Secondary analyses included blood pressure (BP) responses, and effect modification by asthmatic status.
RESULTS:
Achieved mean CAPs and O(3) exposure concentrations were 121.6 +/- 48.0 microg/m(3) and 113.9 +/- 6.6 ppb, respectively. In a categorical analysis, exposure had no consistent effect on HRV indices. However, the dose-response relationship between CAPs mass concentration and HRV indices seemed to vary depending on the presence of O(3). This heterogeneity was statistically significant for the low-frequency component of HRV (p = 0.02) and approached significance for the high-frequency component and time-domain measures of HRV. Exposure to CAPs + O(3) increased diastolic BP by 2.0 mmHg (SE, 1.2; p = 0.02). No other statistically significant changes in BP were observed. Asthmatic status did not modify these effects.
CONCLUSION:
The potentiation by O(3) of CAPs effects on diastolic BP and possibly HRV is of small magnitude in young adults. Further studies are needed to assess potential effects in more vulnerable populations.
Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone.
Environ Health Perspect. 2009 Aug; 117(8): 1287-92Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, Mittleman MA
Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers
Type 1 angiotensin II (AT(1)) receptor has a critical role in the development of load-induced cardiac hypertrophy. Recently, we showed that mechanical stretching of cells activates the AT(1) receptor without the involvement of angiotensin II (AngII) and that this AngII-independent activation is inhibited by the inverse agonistic activity of the AT(1) receptor blocker (ARB), candesartan.
Although the inverse agonist activity of ARBs has been studied in terms of their action on constitutively active AT(1) receptors, the structure-function relationship of the inverse agonism they exert against stretch-induced AT(1) receptor activation has not been fully elucidated. Assays evaluating c-fos gene expression and phosphorylated extracellular signal-regulated protein kinases (ERKs) have shown that olmesartan has strong inverse agonist activities against the constitutively active AT(1) receptor and the stretch-induced activation of AT(1) receptor, respectively.
Ternary drug-receptor interactions, which occur between the hydroxyl group of olmesartan and Tyr(113) and between the carboxyl group of olmesartan and Lys(199) and His(256), were essential for the potent inverse agonist action olmesartan exerts against stretch-induced ERK activation and the constitutive activity of the AT(1)-N111G mutant receptor.
Furthermore, the inverse agonist activity olmesartan exerts against stretch-induced ERK activation requires an additional drug-receptor interaction involving the tetrazole group of olmesartan and Gln(257) of the AT(1) receptor.
These results suggest that multivalent interactions between an inverse agonist and the AT(1) receptor are required to stabilize the receptor in an inactive conformation in response to the distinct processes that lead to an AngII-independent activation of the AT(1) receptor.Hypertension Research advance online publication, 7 August 2009; doi:10.1038/hr.2009.117.
"Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation"
Hypertens Res. 2009 Aug 7; Qin Y, Yasuda N, Akazawa H, Ito K, Kudo Y, Liao CH, Yamamoto R, Miura SI, Saku K, Komuro I
Although the inverse agonist activity of ARBs has been studied in terms of their action on constitutively active AT(1) receptors, the structure-function relationship of the inverse agonism they exert against stretch-induced AT(1) receptor activation has not been fully elucidated. Assays evaluating c-fos gene expression and phosphorylated extracellular signal-regulated protein kinases (ERKs) have shown that olmesartan has strong inverse agonist activities against the constitutively active AT(1) receptor and the stretch-induced activation of AT(1) receptor, respectively.
Ternary drug-receptor interactions, which occur between the hydroxyl group of olmesartan and Tyr(113) and between the carboxyl group of olmesartan and Lys(199) and His(256), were essential for the potent inverse agonist action olmesartan exerts against stretch-induced ERK activation and the constitutive activity of the AT(1)-N111G mutant receptor.
Furthermore, the inverse agonist activity olmesartan exerts against stretch-induced ERK activation requires an additional drug-receptor interaction involving the tetrazole group of olmesartan and Gln(257) of the AT(1) receptor.
These results suggest that multivalent interactions between an inverse agonist and the AT(1) receptor are required to stabilize the receptor in an inactive conformation in response to the distinct processes that lead to an AngII-independent activation of the AT(1) receptor.Hypertension Research advance online publication, 7 August 2009; doi:10.1038/hr.2009.117.
"Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation"
Hypertens Res. 2009 Aug 7; Qin Y, Yasuda N, Akazawa H, Ito K, Kudo Y, Liao CH, Yamamoto R, Miura SI, Saku K, Komuro I
Air pollution exposures and circulating biomarkers of effect
Mechanisms involving oxidative stress and inflammation have been proposed to explain associations of ambient air pollution with cardiovascular morbidity and mortality. Experimental evidence suggests that organic components and ultrafine particles (UFP) are important.
METHODS:
We conducted a panel study of 60 elderly subjects with coronary artery disease living in retirement communities within the Los Angeles, California, air basin. Weekly biomarkers of inflammation included plasma interleukin-6, tumor necrosis factor-alpha soluble receptor II (sTNF-RII), soluble platelet selectin (sP-selectin), and C-reactive protein (CRP). Biomarkers of erythrocyte antioxidant activity included glutathione peroxidase-1 and superoxide dismutase. Exposures included outdoor home daily particle mass [particulate matter < 0.25, 0.25-2.5, and 2.5-10 microm in aerodynamic diameter (PM(0.25), PM(0.25-2.5), PM(2.5-10))], and hourly elemental and black carbon (EC-BC), estimated primary and secondary organic carbon (OC(pri), SOC), particle number (PN), carbon monoxide (CO), and nitrogen oxides-nitrogen dioxide (NO(x)-NO(2)). We analyzed the relation of biomarkers to exposures with mixed effects models adjusted for potential confounders.
RESULTS:
Primary combustion markers (EC-BC, OC(pri), CO, NO(x)-NO(2)), but not SOC, were positively associated with inflammatory biomarkers and inversely associated with erythrocyte anti-oxidant enzymes (n = 578). PN and PM(0.25) were more strongly associated with biomarkers than PM(0.25-2.5). Associations for all exposures were stronger during cooler periods when only OC(pri), PN, and NO(x) were higher. We found weaker associations with statin (sTNF-RII, CRP) and clopidogrel use (sP-selectin).
CONCLUSIONS:
Traffic-related air pollutants are associated with increased systemic inflammation, increased platelet activation, and decreased erythrocyte antioxidant enzyme activity, which may be partly behind air pollutant-related increases in systemic inflammation. Differences in association by particle size, OC fraction, and seasonal period suggest components carried by UFP are important.
"Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms".
Environ Health Perspect. 2009 Aug; 117(8): 1232-8Delfino RJ, Staimer N, Tjoa T, Gillen DL, Polidori A, Arhami M, Kleinman MT, Vaziri ND, Longhurst J, Sioutas C
METHODS:
We conducted a panel study of 60 elderly subjects with coronary artery disease living in retirement communities within the Los Angeles, California, air basin. Weekly biomarkers of inflammation included plasma interleukin-6, tumor necrosis factor-alpha soluble receptor II (sTNF-RII), soluble platelet selectin (sP-selectin), and C-reactive protein (CRP). Biomarkers of erythrocyte antioxidant activity included glutathione peroxidase-1 and superoxide dismutase. Exposures included outdoor home daily particle mass [particulate matter < 0.25, 0.25-2.5, and 2.5-10 microm in aerodynamic diameter (PM(0.25), PM(0.25-2.5), PM(2.5-10))], and hourly elemental and black carbon (EC-BC), estimated primary and secondary organic carbon (OC(pri), SOC), particle number (PN), carbon monoxide (CO), and nitrogen oxides-nitrogen dioxide (NO(x)-NO(2)). We analyzed the relation of biomarkers to exposures with mixed effects models adjusted for potential confounders.
RESULTS:
Primary combustion markers (EC-BC, OC(pri), CO, NO(x)-NO(2)), but not SOC, were positively associated with inflammatory biomarkers and inversely associated with erythrocyte anti-oxidant enzymes (n = 578). PN and PM(0.25) were more strongly associated with biomarkers than PM(0.25-2.5). Associations for all exposures were stronger during cooler periods when only OC(pri), PN, and NO(x) were higher. We found weaker associations with statin (sTNF-RII, CRP) and clopidogrel use (sP-selectin).
CONCLUSIONS:
Traffic-related air pollutants are associated with increased systemic inflammation, increased platelet activation, and decreased erythrocyte antioxidant enzyme activity, which may be partly behind air pollutant-related increases in systemic inflammation. Differences in association by particle size, OC fraction, and seasonal period suggest components carried by UFP are important.
"Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms".
Environ Health Perspect. 2009 Aug; 117(8): 1232-8Delfino RJ, Staimer N, Tjoa T, Gillen DL, Polidori A, Arhami M, Kleinman MT, Vaziri ND, Longhurst J, Sioutas C
Tuesday
Diagnosis of Human Papilloma Virus
Human Papilloma Virus is a sexually transmitted virus that is being investigated for about 30 years and is a risk factor for women's health because, if left unchallenged, can cause cervical cancer. In most cases, treatment of this condition has a high percentage of effectiveness.
Thus, the center adds a new analysis service to those already offered: hepatitis C, HIV, viral encephalitis (human and equine), dengue, rubella and chlamydia, among others.
Related :
What is the Human Papilloma Virus?
HPV Clinical Trial: Human Papilloma Virus (HPV) Vaccination
Approximately Half Of Penile Cancers Associated To Human Papilloma Virus
Human papilloma virus infection prior to coitarche
Oropharyngeal Carcinoma: Better Outlook From Human Papilloma Virus
Thursday
Retinal vessel diameters and risk of hypertension
To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort.
METHODS:
The Multi-Ethnic Study of Atherosclerosis is a population-based study of subclinical cardiovascular disease among white, African-American, Hispanic, and Chinese American adults aged 45-84 years. Retinal vessel diameters were measured using a standardized imaging software at the second examination (considered baseline in this analysis) and summarized as the central retinal artery/vein equivalent.
Presence of retinopathy and retinal focal arteriolar narrowing and arteriovenous nicking was assessed by trained graders. Incidence of hypertension was defined among participants at risk as systolic blood pressure at least 140 mmHg, diastolic blood pressure at least 90 mmHg, or use of an antihypertensive medication.
RESULTS:
Of the initial 6237 participants at baseline, 2583 were at risk of hypertension. After 3.2 +/- 0.5 years of follow-up, 448 (17.3%) participants developed hypertension. After adjusting for age, sex, race/ethnicity, the average of mean arterial blood pressure in the first and second examination, and other vascular risk factors, persons with narrower retinal arteriolar diameter and wider venular diameter at baseline were more likely to develop hypertension [odds ratio per SD decrease in central retinal artery equivalent 1.20, 95% confidence intervals 1.02, 1.42; and odds ratio per SD increase in central retinal vein equivalent 1.18, 95% confidence interval 1.02, 1.37]. Persons with focal arteriolar narrowing were also more likely to develop hypertension (odds ratio 1.80, 95% confidence interval 1.09, 2.97).
CONCLUSION:
Findings from this multiethnic population confirm that narrower retinal arteriolar diameter and wider venular diameter are associated with the development of hypertension independent of traditional risk factors.
"Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis"
J Hypertens. 2009 Aug 12; Kawasaki R, Cheung N, Wang JJ, Klein R, Klein BE, Cotch MF, Sharrett AR, Shea S, Islam FA, Wong TY
METHODS:
The Multi-Ethnic Study of Atherosclerosis is a population-based study of subclinical cardiovascular disease among white, African-American, Hispanic, and Chinese American adults aged 45-84 years. Retinal vessel diameters were measured using a standardized imaging software at the second examination (considered baseline in this analysis) and summarized as the central retinal artery/vein equivalent.
Presence of retinopathy and retinal focal arteriolar narrowing and arteriovenous nicking was assessed by trained graders. Incidence of hypertension was defined among participants at risk as systolic blood pressure at least 140 mmHg, diastolic blood pressure at least 90 mmHg, or use of an antihypertensive medication.
RESULTS:
Of the initial 6237 participants at baseline, 2583 were at risk of hypertension. After 3.2 +/- 0.5 years of follow-up, 448 (17.3%) participants developed hypertension. After adjusting for age, sex, race/ethnicity, the average of mean arterial blood pressure in the first and second examination, and other vascular risk factors, persons with narrower retinal arteriolar diameter and wider venular diameter at baseline were more likely to develop hypertension [odds ratio per SD decrease in central retinal artery equivalent 1.20, 95% confidence intervals 1.02, 1.42; and odds ratio per SD increase in central retinal vein equivalent 1.18, 95% confidence interval 1.02, 1.37]. Persons with focal arteriolar narrowing were also more likely to develop hypertension (odds ratio 1.80, 95% confidence interval 1.09, 2.97).
CONCLUSION:
Findings from this multiethnic population confirm that narrower retinal arteriolar diameter and wider venular diameter are associated with the development of hypertension independent of traditional risk factors.
"Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis"
J Hypertens. 2009 Aug 12; Kawasaki R, Cheung N, Wang JJ, Klein R, Klein BE, Cotch MF, Sharrett AR, Shea S, Islam FA, Wong TY
Tuesday
Biomarkers of myocyte injury in heart failure
Markers of cardiac myocyte injury have contributed over the years to the diagnosis and to the assessment of size of myocardial infarction. Recent evidence suggests that measurement of the release of cardiac contractile proteins into the bloodstream at lower levels may be useful in the clinical assessment of patients who have acute or chronic heart failure.
The advent of a new generation of high-sensitivity immunoassays for cardiac troponins offers challenges for scientists and clinicians and will likely change the understanding and interpretation of cardiac injury.
"Biomarkers of myocyte injury in heart failure"
Latini R, Masson S Heart Fail Clin. 2009 Oct ; 5(4): 529-36 (Hubmed.org)
Related:
New Biomarkers Found In Heart Failure Syndrome
The advent of a new generation of high-sensitivity immunoassays for cardiac troponins offers challenges for scientists and clinicians and will likely change the understanding and interpretation of cardiac injury.
"Biomarkers of myocyte injury in heart failure"
Latini R, Masson S Heart Fail Clin. 2009 Oct ; 5(4): 529-36 (Hubmed.org)
Related:
New Biomarkers Found In Heart Failure Syndrome
... recently proposed by Prof Eugene Braunwald, according to which biomarkers can reflect/characterize different aspects of HF: inflammation oxidative stress extracellular-matrix remodeling neurohormones myocyte injury myocyte stress" ...Cardiac Troponin and Outcome in Acute Heart Failure
An elevation in cardiac troponin can indicate the presence of myocyte injury or death.19 This model recognizes progressive myocyte loss as a prominent pathophysiological mechanism in the evolution of cardiac dysfunction and acute ...Biomarkers in heart failure
Potential markers of HF include neuro-hormonal mediators, markers of myocyte injury, and indicators of systemic inflammation. Among these, the BNP and NT-pro-BNP are the most widely studied and appear to be useful in patientsAcute Heart Failure: An Evidence-Based Approach
Regardless of the underlying cause or the type of heart failure, cardiac myocyte injury leads to systemic neurohumoral activation and left ventricular remodeling, which in turn alters left ventricular chamber geometry and function. ...
Monday
Natriuretic peptides in the diagnosis and management of chronic heart failure
Circulating levels of the brain natriuretic peptide system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have heart failure but also for the general population and other patient groups.
Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the brain natriuretic peptide system are emerging that may improve the diagnostic and prognostic value of brain natriuretic peptide.
Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases brain natriuretic peptide levels) may help to further refine the use of components of the brain natriuretic peptide system as biomarkers.
"Natriuretic peptides in the diagnosis and management of chronic heart failure"
Boerrigter G, Costello-Boerrigter LC, Burnett JC
Heart Fail Clin. 2009 Oct ; 5(4): 501-14 (Hubmed.org)
Related:
Asymmetrical myocardial expression of natriuretic peptides in heart failure
Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the brain natriuretic peptide system are emerging that may improve the diagnostic and prognostic value of brain natriuretic peptide.
Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases brain natriuretic peptide levels) may help to further refine the use of components of the brain natriuretic peptide system as biomarkers.
"Natriuretic peptides in the diagnosis and management of chronic heart failure"
Boerrigter G, Costello-Boerrigter LC, Burnett JC
Heart Fail Clin. 2009 Oct ; 5(4): 501-14 (Hubmed.org)
Related:
Asymmetrical myocardial expression of natriuretic peptides in heart failure
Aim of this study was to evaluate possible changes in brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) mRNA expression in the anterior/anterior lateral region (pacing site, PS) as compared to the infero-septal regionEU approves Diovan to treat people with heart failure
a number of prognostic markers for insolvent outcomes, including planner natriuretic peptide (BNP), norepinephrine (NE) Anand I et al. Changes in Brain Natriuretic Peptide and Norepinephrine All about Time are Related to SubsequentVariability of N-Terminal Probrain Natriuretic Peptide in Stable heart failure
We investigated the variability of N-terminal probrain natriuretic peptide (NT-proBNP) and its relation to known confounding variables in patients with stable chronic heart failure who were on a stable optimized medication ...Heart Failure - Women More At Risk Than Men
For example, "normal" values for brain natriuretic peptide—a biomarker that is being used more frequently to identify patients with symptoms of heart failure and stratify patients by risk—are higher for women versus men and abnormal valuesPalatin Technologies, Inc. Receives U.S. Patent Allowance in heart failure
... Inc. (NYSE Amex: PTN) announced today that it has received a Notice of Allowance from the US Patent and Trademark Office for its US Patent Application Number 11/694260, titled “Cyclic Natriuretic Peptide Constructs.
Friday
The effects of hormone replacement therapy on myocardial performance
The results of the studies in which the effect of hormone replacement therapy (HRT) on cardiac function have been evaluated are rather disputable. In these studies, cardiac function was evaluated with conventional echocardiographic methods.
This study was planned in order to investigate the effects of HRT on myocardial velocities and myocardial performance index (MPI) in healthy early postmenopausal women. Method In a prospective, controlled study, 60 healthy postmenopausal women were assigned to two groups (32 in the HRT group and 28 in the control group).
After conventional echocardiographic parameters were measured, tissue Doppler echocardiography recordings were obtained from the mitral and tricuspid annulus. Systolic myocardial velocity (Sm), early and late diastolic myocardial velocities (Em and Am) and time intervals were measured and MPI was calculated. Then the symptom-limited exercise stress test using the Bruce protocol was performed.
After 3 and 6 months of HRT (oral 0.625 mg conjugated estrogen + 2.5 mg medroxyprogesterone acetate/day), the same examinations were repeated. The effects of HRT on myocardial velocities, MPI and exercise time were evaluated at the 3rd and 6th months. Results The parameters of the control group remained statistically unchanged during the study.
HRT did not have any effect on segmental and mean left ventricular (LV) Sm or right ventricular (RV) Sm. However, LV Em/Am and RV Em/Am ratios significantly increased at the 6th month of HRT, and LV and RV MPI values were observed to decrease significantly as compared to basal values.
Additionally, a significant increase was observed in exercise duration and metabolic equivalent values after 3 months of HRT, and this increase continued at the 6th month as well. The favorable changes in all parameters in the HRT group were significantly different from those of the control group.
Conclusion Data obtained in this study suggest that HRT is not only effective for treating menopausal complaints but also increases cardiovascular performance by improving especially diastolic functions in early postmenopausal women.
The effects of hormone replacement therapy on myocardial performance in early postmenopausal women.
Climacteric. 2009 Aug 11; 1-14Duzenli MA, Ozdemir K, Sokmen A, Gezginc K, Soylu A, Celik C, Altunkeser BB, Tokac M
Related:
Poor children receive surgery to cure congenital heart diseases
Chandigarh to financially assist congenital heart diseases ...
This study was planned in order to investigate the effects of HRT on myocardial velocities and myocardial performance index (MPI) in healthy early postmenopausal women. Method In a prospective, controlled study, 60 healthy postmenopausal women were assigned to two groups (32 in the HRT group and 28 in the control group).
After conventional echocardiographic parameters were measured, tissue Doppler echocardiography recordings were obtained from the mitral and tricuspid annulus. Systolic myocardial velocity (Sm), early and late diastolic myocardial velocities (Em and Am) and time intervals were measured and MPI was calculated. Then the symptom-limited exercise stress test using the Bruce protocol was performed.
After 3 and 6 months of HRT (oral 0.625 mg conjugated estrogen + 2.5 mg medroxyprogesterone acetate/day), the same examinations were repeated. The effects of HRT on myocardial velocities, MPI and exercise time were evaluated at the 3rd and 6th months. Results The parameters of the control group remained statistically unchanged during the study.
HRT did not have any effect on segmental and mean left ventricular (LV) Sm or right ventricular (RV) Sm. However, LV Em/Am and RV Em/Am ratios significantly increased at the 6th month of HRT, and LV and RV MPI values were observed to decrease significantly as compared to basal values.
Additionally, a significant increase was observed in exercise duration and metabolic equivalent values after 3 months of HRT, and this increase continued at the 6th month as well. The favorable changes in all parameters in the HRT group were significantly different from those of the control group.
Conclusion Data obtained in this study suggest that HRT is not only effective for treating menopausal complaints but also increases cardiovascular performance by improving especially diastolic functions in early postmenopausal women.
The effects of hormone replacement therapy on myocardial performance in early postmenopausal women.
Climacteric. 2009 Aug 11; 1-14Duzenli MA, Ozdemir K, Sokmen A, Gezginc K, Soylu A, Celik C, Altunkeser BB, Tokac M
Related:
Poor children receive surgery to cure congenital heart diseases
viet nam news, poor children receive surgery to cure congenital heart diseases. viet nam news, vietnam - 10 hours ago … struggling to make ends meet, had to sell their house, garden and cows … following rising cases of congenital heart ...
Chandigarh to financially assist congenital heart diseases ...
Chandigarh: The Health Department, Chandigarh Administration launched a pilot project for providing financial assistance to the needy children who are suffering with Congenital Heart Diseases for their surgery at PGI, Chandigarh. ...Postoperative imaging in cyanotic congenital heart diseases: part ...
american journal of roentgenology rodríguez, e., et al. - radiologists need a solid knowledge of the surgical procedures used to treat patients with cyanotic congenital heart diseases to identify what constitutes normal postoperative ...Key Points in Congenital Heart Diseases
The Key Points in Congenital Heart Diseases. Key Points The term “congenital heart defect” describes a structural problem (or defect) in the heart that is present at birth. The defects occur during the development of a baby's heart. ...
Wednesday
After implantation of valved bovine jugular vein conduit in complex congenital heart diseases
To study the inflammation response and the biocompatibility of valved bovine jugular vein conduit (BJVC) and valved bovine jugular vein patch (VBJV-P) in treating complex congenital heart disease (CHD).
METHODS:
From December 2007 to March 2008, 16 patients with complex CHD were treated. Of 16 patients, 6 underwent conjunction right ventricular to pulmonary artery with BJVC and broaden right ventricular outflow tract (RVOT) with VBJV-P (BJVC group), and 10 underwent broaden RVOT with self pericardial patch (control group). In BJVC group, there were 3 males and 3 females, aging (5.6 +/- 3.6) years, and including 1 case of type I truncus arteriosus, 1 case of type I truncus arteriosus with ventricular septal defect and patent foramen ovale, 1 case of congenital pulmonary atresia with ventricular septal defect and patent arterial duct, and 3 cases of Fallot's tetrad.
In control group, there were 5 males and 5 females, aging (4.3 +/- 3.1) years, all being Fallot's tetrad. The periphery vein blood of the two groups was collected during operation and after operation, and the levels of cytokine were detected with ELISA method. Meanwhile the clinical data of the two groups were collected.
RESULTS:
There were no significant differences at levels of TNF-alpha and IL-6 between. There were no significant differences at levels of IL-6 and IL-10 within groups bothin control group
The X-ray films showed no abnormality in BJVC group and control group before operation and after operation. No hepatic and renal dysfunction occurred in control group; and 2 patients had hepatic dysfunction, which may be caused by antibiotics.
CONCLUSION:
BJVC has a good biocompatibility in treating complexty CHD.
Changes of seral TNF-alpha, IL-6 and IL-10 level after implantation of valved bovine jugular vein conduit in complex congenital heart diseases
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul; 23(7): 877-81Fang Y, Hu J, Wu Z, Pu D
Related:
Treating Pediatric Congenital Heart Diseases
HealtH: 75% of Congenital Heart Diseases Curable With Surgery
Congenital heart diseases classsification
Congenital heart diseases: post-operative appearance
Congenital Heart Diseases
how to prevent congenital heart diseases
when do cyanotic congenital heart diseases present?
The Frank Murphy Memorial Lecture 2008 - Congenital Heart Diseases
Central Pulmonary Artery Histopathology in Patients With Cyanotic
Echocardiography in Adult Congenital Heart Diseases
An Overview of Congenital Heart Diseases
METHODS:
From December 2007 to March 2008, 16 patients with complex CHD were treated. Of 16 patients, 6 underwent conjunction right ventricular to pulmonary artery with BJVC and broaden right ventricular outflow tract (RVOT) with VBJV-P (BJVC group), and 10 underwent broaden RVOT with self pericardial patch (control group). In BJVC group, there were 3 males and 3 females, aging (5.6 +/- 3.6) years, and including 1 case of type I truncus arteriosus, 1 case of type I truncus arteriosus with ventricular septal defect and patent foramen ovale, 1 case of congenital pulmonary atresia with ventricular septal defect and patent arterial duct, and 3 cases of Fallot's tetrad.
In control group, there were 5 males and 5 females, aging (4.3 +/- 3.1) years, all being Fallot's tetrad. The periphery vein blood of the two groups was collected during operation and after operation, and the levels of cytokine were detected with ELISA method. Meanwhile the clinical data of the two groups were collected.
RESULTS:
There were no significant differences at levels of TNF-alpha and IL-6 between. There were no significant differences at levels of IL-6 and IL-10 within groups bothin control group
The X-ray films showed no abnormality in BJVC group and control group before operation and after operation. No hepatic and renal dysfunction occurred in control group; and 2 patients had hepatic dysfunction, which may be caused by antibiotics.
CONCLUSION:
BJVC has a good biocompatibility in treating complexty CHD.
Changes of seral TNF-alpha, IL-6 and IL-10 level after implantation of valved bovine jugular vein conduit in complex congenital heart diseases
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul; 23(7): 877-81Fang Y, Hu J, Wu Z, Pu D
Related:
Treating Pediatric Congenital Heart Diseases
HealtH: 75% of Congenital Heart Diseases Curable With Surgery
Congenital heart diseases classsification
Congenital heart diseases: post-operative appearance
Congenital Heart Diseases
how to prevent congenital heart diseases
when do cyanotic congenital heart diseases present?
The Frank Murphy Memorial Lecture 2008 - Congenital Heart Diseases
Central Pulmonary Artery Histopathology in Patients With Cyanotic
Echocardiography in Adult Congenital Heart Diseases
An Overview of Congenital Heart Diseases
Influence of ischemia-reperfusion on expression of hyperpolarization
To study the influence of ischemia-reperfusion on the expression of the hyperpolarization activated cyclicnucleotide gated cation channel 4 (HCN4) and to discuss the mechanism of functional disturbance of sinoatrial node tissue (SANT) after ischemia reperfusion injury (IRI).
METHODS:
Eighty five healthy adult rabbits, weighing 2-3 kg, were randomly divided into 3 groups: control group [a suture passed under the root section of right coronary artery (RCA) without ligation, n=5], experimental group A (occluding the root section of RCA for 30 minutes, then loosening the root 2, 4, 8 and 16 hours, n=10), experimental group B (occluding the root section of RCA for 1 hour, then loosening the root 2, 4, 8 and 16 hours, n=10).
At the end of the reperfusion, the SANT was cut off to do histopathological, transmission electron microscopical and immunohistochemical examinations and semi-quantitative analysis.
RESULTS:
The result of HE staining showed that patho-injure of sinoatrial node cell (SANC) happened in experimental groups A and B after 2 hours of reperfusion, the longer the reperfusion time was, the more serious patho-injure of SANC was after 4 and 8 hours of reperfusion, SANC reached peak of damage after 8 to 16 hours of reperfusion; patho-injure of SANC was more serious in experimental group B than in experimental group A at the same reperfusion time.
Immunohistochemical staining showed that the expression of HCN4 located in cellular membrane and cytoplasm in the central area of SANC and gradually decreased from the center to borderline.
CONCLUSION:
IRI is harmful to the morphous and structure of SANC, and effects the expression of HCN4 of SANC, which is concerned with functional disturbance and arrhythmia.
"Experimental study on influence of ischemia-reperfusion on expression of hyperpolarization activated cyclicnucleotide gated cation channel 4 of sinoatrial node cells in rabbits in vivo"
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul; 23(7): 856-60Fu Y, Liao B, Yu F, Deng M, Feng Z, Zhan F, Li X, Wan J
METHODS:
Eighty five healthy adult rabbits, weighing 2-3 kg, were randomly divided into 3 groups: control group [a suture passed under the root section of right coronary artery (RCA) without ligation, n=5], experimental group A (occluding the root section of RCA for 30 minutes, then loosening the root 2, 4, 8 and 16 hours, n=10), experimental group B (occluding the root section of RCA for 1 hour, then loosening the root 2, 4, 8 and 16 hours, n=10).
At the end of the reperfusion, the SANT was cut off to do histopathological, transmission electron microscopical and immunohistochemical examinations and semi-quantitative analysis.
RESULTS:
The result of HE staining showed that patho-injure of sinoatrial node cell (SANC) happened in experimental groups A and B after 2 hours of reperfusion, the longer the reperfusion time was, the more serious patho-injure of SANC was after 4 and 8 hours of reperfusion, SANC reached peak of damage after 8 to 16 hours of reperfusion; patho-injure of SANC was more serious in experimental group B than in experimental group A at the same reperfusion time.
Immunohistochemical staining showed that the expression of HCN4 located in cellular membrane and cytoplasm in the central area of SANC and gradually decreased from the center to borderline.
CONCLUSION:
IRI is harmful to the morphous and structure of SANC, and effects the expression of HCN4 of SANC, which is concerned with functional disturbance and arrhythmia.
"Experimental study on influence of ischemia-reperfusion on expression of hyperpolarization activated cyclicnucleotide gated cation channel 4 of sinoatrial node cells in rabbits in vivo"
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul; 23(7): 856-60Fu Y, Liao B, Yu F, Deng M, Feng Z, Zhan F, Li X, Wan J
Subscribe to:
Posts (Atom)