To study the inflammation response and the biocompatibility of valved bovine jugular vein conduit (BJVC) and valved bovine jugular vein patch (VBJV-P) in treating complex congenital heart disease (CHD).
METHODS:
From December 2007 to March 2008, 16 patients with complex CHD were treated. Of 16 patients, 6 underwent conjunction right ventricular to pulmonary artery with BJVC and broaden right ventricular outflow tract (RVOT) with VBJV-P (BJVC group), and 10 underwent broaden RVOT with self pericardial patch (control group). In BJVC group, there were 3 males and 3 females, aging (5.6 +/- 3.6) years, and including 1 case of type I truncus arteriosus, 1 case of type I truncus arteriosus with ventricular septal defect and patent foramen ovale, 1 case of congenital pulmonary atresia with ventricular septal defect and patent arterial duct, and 3 cases of Fallot's tetrad.
In control group, there were 5 males and 5 females, aging (4.3 +/- 3.1) years, all being Fallot's tetrad. The periphery vein blood of the two groups was collected during operation and after operation, and the levels of cytokine were detected with ELISA method. Meanwhile the clinical data of the two groups were collected.
RESULTS:
There were no significant differences at levels of TNF-alpha and IL-6 between. There were no significant differences at levels of IL-6 and IL-10 within groups bothin control group
The X-ray films showed no abnormality in BJVC group and control group before operation and after operation. No hepatic and renal dysfunction occurred in control group; and 2 patients had hepatic dysfunction, which may be caused by antibiotics.
CONCLUSION:
BJVC has a good biocompatibility in treating complexty CHD.
Changes of seral TNF-alpha, IL-6 and IL-10 level after implantation of valved bovine jugular vein conduit in complex congenital heart diseases
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul; 23(7): 877-81Fang Y, Hu J, Wu Z, Pu D
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