Markers of cardiac myocyte injury have contributed over the years to the diagnosis and to the assessment of size of myocardial infarction. Recent evidence suggests that measurement of the release of cardiac contractile proteins into the bloodstream at lower levels may be useful in the clinical assessment of patients who have acute or chronic heart failure.
The advent of a new generation of high-sensitivity immunoassays for cardiac troponins offers challenges for scientists and clinicians and will likely change the understanding and interpretation of cardiac injury.
"Biomarkers of myocyte injury in heart failure"
Latini R, Masson S Heart Fail Clin. 2009 Oct ; 5(4): 529-36 (Hubmed.org)
Related:
New Biomarkers Found In Heart Failure Syndrome
The advent of a new generation of high-sensitivity immunoassays for cardiac troponins offers challenges for scientists and clinicians and will likely change the understanding and interpretation of cardiac injury.
"Biomarkers of myocyte injury in heart failure"
Latini R, Masson S Heart Fail Clin. 2009 Oct ; 5(4): 529-36 (Hubmed.org)
Related:
New Biomarkers Found In Heart Failure Syndrome
... recently proposed by Prof Eugene Braunwald, according to which biomarkers can reflect/characterize different aspects of HF: inflammation oxidative stress extracellular-matrix remodeling neurohormones myocyte injury myocyte stress" ...Cardiac Troponin and Outcome in Acute Heart Failure
An elevation in cardiac troponin can indicate the presence of myocyte injury or death.19 This model recognizes progressive myocyte loss as a prominent pathophysiological mechanism in the evolution of cardiac dysfunction and acute ...Biomarkers in heart failure
Potential markers of HF include neuro-hormonal mediators, markers of myocyte injury, and indicators of systemic inflammation. Among these, the BNP and NT-pro-BNP are the most widely studied and appear to be useful in patientsAcute Heart Failure: An Evidence-Based Approach
Regardless of the underlying cause or the type of heart failure, cardiac myocyte injury leads to systemic neurohumoral activation and left ventricular remodeling, which in turn alters left ventricular chamber geometry and function. ...
