Circulating levels of the brain natriuretic peptide system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have heart failure but also for the general population and other patient groups.
Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the brain natriuretic peptide system are emerging that may improve the diagnostic and prognostic value of brain natriuretic peptide.
Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases brain natriuretic peptide levels) may help to further refine the use of components of the brain natriuretic peptide system as biomarkers.
"Natriuretic peptides in the diagnosis and management of chronic heart failure"
Boerrigter G, Costello-Boerrigter LC, Burnett JC
Heart Fail Clin. 2009 Oct ; 5(4): 501-14 (Hubmed.org)
Related:
Asymmetrical myocardial expression of natriuretic peptides in heart failure
Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the brain natriuretic peptide system are emerging that may improve the diagnostic and prognostic value of brain natriuretic peptide.
Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases brain natriuretic peptide levels) may help to further refine the use of components of the brain natriuretic peptide system as biomarkers.
"Natriuretic peptides in the diagnosis and management of chronic heart failure"
Boerrigter G, Costello-Boerrigter LC, Burnett JC
Heart Fail Clin. 2009 Oct ; 5(4): 501-14 (Hubmed.org)
Related:
Asymmetrical myocardial expression of natriuretic peptides in heart failure
Aim of this study was to evaluate possible changes in brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) mRNA expression in the anterior/anterior lateral region (pacing site, PS) as compared to the infero-septal regionEU approves Diovan to treat people with heart failure
a number of prognostic markers for insolvent outcomes, including planner natriuretic peptide (BNP), norepinephrine (NE) Anand I et al. Changes in Brain Natriuretic Peptide and Norepinephrine All about Time are Related to SubsequentVariability of N-Terminal Probrain Natriuretic Peptide in Stable heart failure
We investigated the variability of N-terminal probrain natriuretic peptide (NT-proBNP) and its relation to known confounding variables in patients with stable chronic heart failure who were on a stable optimized medication ...Heart Failure - Women More At Risk Than Men
For example, "normal" values for brain natriuretic peptide—a biomarker that is being used more frequently to identify patients with symptoms of heart failure and stratify patients by risk—are higher for women versus men and abnormal valuesPalatin Technologies, Inc. Receives U.S. Patent Allowance in heart failure
... Inc. (NYSE Amex: PTN) announced today that it has received a Notice of Allowance from the US Patent and Trademark Office for its US Patent Application Number 11/694260, titled “Cyclic Natriuretic Peptide Constructs.
